time has come to move them on.
Here, Press Association Sport takes a look at each Premier League squad and highlights cases where it is probably in the best interests of both club and player for a transfer to happen before 11pm tonight
Arsenal
Right-back Mathieu Debuchy's Arsenal career has never really got going due to injury and the emergence of Hector Bellerin
The 31-year-old is ready for a new challenge - he spent the back end of last season on loan at Bordeaux - and Arsenal appear happy to cash out on a player they spent £10million on two years ago
The only hurdle to his exit appears to be a calf injury.
Bournemouth
Since joining the Premier League, Bournemouth have made a policy of signing young players with plenty of upside so there are not any obvious options for them to offload
Veteran striker Glenn Murray has been loaned to Brighton for the season, and could be moved on after that.
Burnley
Striker Lukas Jutkiewicz has not scored for Burnley for two and a half seasons and, following the arrival of Patrick Bamford on loan from Chelsea, he has dropped to fifth choice strike option at Turf Moor
Chelsea
Juan Cuadrado has not settled at Stamford Bridge since his £23million arrival 18 months ago, and spent last term on loan at new boss Antonio Conte's former club Juventus
Conte took him on Chelsea's pre-season tour, and declared him part of his plans, but has since preferred Victor Moses in the early weeks of the season
Crystal Palace
Fraizer Campbell has been frozen out of the first-team picture by boss Alan Pardew and in this transfer window he has seen the club spend a record amount on Christian Benteke and bring in Loic Remy on loan
Campbell had an injury-interrupted pre-season and has been linked with a move to the Championship
Everton
Oumar Niasse looms as an expensive flop after Everton paid a reported £13.5million for the forward in January
The 26-year-old has made just two starts since - he was substituted in both - and has not been given a squad number by new boss Ronald Koeman
Hull
The Tigers are not in a position to cull anyone after injuries left them with just 13 fit senior players to start the campaign
Leicester
Former Switzerland captain Gokhan Inler has reportedly told Claudio Ranieri that he wants a move after struggling for first-team football during the Foxes' unlikely run to the title
I nler was Leicester's star signing last summer, but it appears Ranieri is content to grant the wish of a player who he has praised for his professionalism
Liverpool
Jurgen Klopp has done all his buying so it is set to be all about the outgoings from Anfield on transfer deadline day
Mario Balotelli is set to headline those with his unhappy stay at Liverpool likely to end with reports the striker is in advanced talks with Ligue 1 club Nice
Klopp is also keen to move on Serbia international Lazar Markovic, with Newcastle linked
Manchester City
Pep Guardiola has been unafraid to wield the axe since arriving this summer - see Joe Hart - and more big names are set to follow
Wilfried Bony has never got going at City due to injury, national-team duty while he also contracted malaria
When he has got his chances he has not helped himself by missing some sitters
Samir Nasri has hardly endeared himself to the Spaniard's strict style and has slipped down the pecking order this summer
Guardiola is also detached enough from the £42million purchase of Eliaquim Mangala to cut City's losses on the defender
Manchester United
Jose Mourinho's arrival has been bad news for former Germany skipper Bastian Schweinsteiger who appears resigned to the fact his future is somewhere other than Old Trafford
Whether his move will happen this window is debatable, with Schweinsteiger saying he will not sign for another European club and the MLS window having already closed
Middlesbrough
Alex Baptiste was signed last summer, but played no part in Middlesbrough's promotion-winning campaign as he was loaned to Sheffield United
The 30-year-old can play across the back four, but this summer Boro have brought in five defenders - Antonio Barragan, Bernardo Espinosa, Jordan McGhee, Fabio and, most recently, Calum Chambers on a season-long loan from Arsenal
Southampton
Saints have no obvious need to sell on transfer deadline day as new boss Claude Puel has reinvested the funds made from the sales of Graziano Pelle and Sadio Mane
Stoke
Centre-half Dionatan Teixeira has hardly featured since joining in 2014
The 24-year-old Brazilian failed even to make Stoke's EFL Cup squad this month and had been linked with a move to Orlando City earlier in the summer
Sunderland
Billy Jones will always have a place in Sunderland fans' hearts, after scoring in the 3-0 home defeat of Newcastle last season
And after seeing plenty of pre-season action, he could be forgiven for thinking he might figure more at right-back this season - particularly as on-loan Tottenham man DeAndre Yedlin will not be returning
However, the recent arrivals of Javier Manquillo and Donald Love have effectively relegated him to third choice for the role
Swansea
Boss Francesco Guidolin has stated that striker Marvin Emnes and left-sided player Franck Tabanou are not in his plans with both having played little part last season
Tottenham
Boss Mauricio Pochettino has already moved on players such as Nacer Chadli, Yedlin and Ryan Mason who arguably would provide depth in a season when they will hope to mount Premier League and Champions League challenges
Nabil Bentaleb and Federico Fazio have gone out on loan so further exits may be unlikely
Watford
Juan Carlos Paredes made just seven starts last season and has seen new boss Walter Mazzarri substantially add to his defensive depth this summer with Christian Kabasele, Camilo Zuniga, Brice Dja Djedie, Younes Kaboul, Daryl Janmaat and Adrian Mariappa while loaning in Chelsea's Kenedy, who can play at full-back
West Brom
Rickie Lambert has made just five starts for West Brom since joining the club last summer
Boss Tony Pulis said at the back end of last season that the former England striker, who played at the World Cup two years ago, could be let go on a free transfer although that is still yet to happen with uncertainty over fellow forward Saido Berahino's future
West Ham
Diafra Sakho submitted a transfer request earlier this summer and the arrival of Simone Zaza may now have paved the way for a move
The striker had previously almost gone to West Brom, only to fail a medical, while a fee had reportedly been agreed with Sunderland before Sam Allardyce left to take the England job
Source : PA
Source: PA