Lampard, Cole and Essien were controversially left on the bench by former manager Andre Villas-Boas last month as Chelsea crashed to a 3-1 first leg defeat in Naples.
However all three players were named in caretaker Roberto Di Matteo's starting XI at Stamford Bridge as the Blues attempt to overturn a two-goal deficit against the Serie A side.
Chelsea: Cech; Ivanovic, Terry, David Luiz, Cole; Essien, Ramires, Lampard; Juan Mata, Drogba, Sturridge
Napoli: De Sanctis; Aronica, Cannavaro, Campagnaro; Maggio, Inler, Gargano, Zuniga; Hamsik, Cavani, Lavezzi
Source: AFP
Source: AFP