The Football Association has confirmed defenders Ben Chilwell and Kieran Trippier have both left the England camp and will not feature in Wednesday's game against Denmark.
Sunday's 2-1 win over Belgium saw England move to the top of Group 2 in the UEFA Nations League and Gareth Southgate's men will hope to keep their unbeaten start to the campaign going when they face Denmark.
Chilwell, who did not feature in either of England's games during this international break, has returned to Chelsea for treatment on a foot injury which he was carrying heading into the interval. There's no mention as to whether that is related to the heel injury he was carrying when he arrived at Stamford Bridge.
As for Trippier, he has been allowed to leave the camp for personal reasons, leaving Southgate with 28 players to consider for Wednesday's game.
Losing both players presents Southgate with somewhat of a conundrum. Chilwell was the only natural left back in the squad and it was Trippier who was deputising for the Chelsea man, so Southgate may have to get creative.
One option could be to turn to Arsenal's Bukayo Saka, who is primarily a winger but impressed last season in a defensive role for the Gunners.
If Southgate wants to think further outside the box, Arsenal's Ainsley Maitland-Niles has experience in the position, while Chelsea right back Reece James has filled in as an emergency left back in the past.
Another issue for Southgate to consider is the fitness of Tottenham striker Harry Kane, who is thought to be suffering from fatigue after a hectic start to the season.
José Mourinho has previously pleaded with Southgate to protect Kane during the current international break, and up until this point, the England boss has obliged, giving Kane just 24 minutes against Belgium.
Source : 90min